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Design and Analysis of Cluster Randomization Trials in Health Research
by Allan Donner, Neil Klar
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Design and Analysis of Cluster Randomization Trials In Current Issues in the Design of Cluster Randomization Trials Allan Donner PhD FRSC Department of Epidemiology and Biostatistics The University of Western Ontario London Canada Robarts Clinical Trials Robarts Research Institute London Canada What Are Cluster Randomization Trials analysis • CLUSTER RANDOMIZATION TRIALS Design and Analysis of Cluster Randomization Trials in Design and Analysis of Cluster Randomization Trials in Health Research Allan Donner Neil Klar on FREE shipping on qualifying offers A cluster randomization trial is one in which intact social units or clusters of individuals are randomized to different intervention groups Trials randomizing clusters have become particularly widespread in the evaluation of nontherapeutic Design and Analysis of Cluster Randomization Trials in Terry N Flynn Design and Analysis of Cluster Randomization Trials in Health Research Allan Donner and Neil Klar London Arnold 2000 pp178 £3500 How to design efficient cluster randomised trials The BMJ Cluster randomised trials CRTs involve randomisation of groups clusters of individuals to control or intervention conditions1 The CRT design is commonly used to evaluate nondrug interventions such as policy and service delivery interventions Its use is likely to grow as we move towards the learning healthcare system2 and large simple trials3 Design and Analysis of Cluster Randomization Trials in 12 What is the impact of cluster randomization on the design and analysis of a trial 13 Quantifying the effect of clustering 14 Randomized versus nonrandomized comparisons 15 The unit of inference 16 Terminology what’s in a name 2 The historical development of cluster randomized trials 21 Randomized trials before 1950 Design and Analysis of Cluster Randomization Trials In Unit of Randomization vs Unit of Analysis A key property of cluster randomization trials is that inferences are frequently intended to apply at the individual level while randomization is at the cluster or group level Thus the unit of randomization may be different from the unit of analysis In this case the lack of independence among A 20 Minute Introduction to Cluster Randomised Trials A cluster randomised trial is a study design which randomises groups of participants to each arm of a study rather than individuals This is done when it would be difficult give a new treatment to an individual within a community or social group without it affecting the outcome in the standard care arm of the study Design and Analysis of GroupRandomized Trials A Review We review recent developments in the design and analysis of grouprandomized trials GRTs Regarding design we summarize developments in estimates of intraclass correlation power analysis matched designs designs involving one group per condition and designs in which individuals are randomized to receive treatments in groups
